BIOL 230 Lecture Guide - Cros-Presentation ofEndogenous Antigens to MHC-II Molecules

Fig. 8: Cross-Presentation of Endogenous Antigens to MHC-II Molecules
by a Dendritic Cell Through Autophagy

Endogenous antigens can be cross-presented to MHC-II molecules by certain dendritic cells through a cellular process called autophagy.

1. Cellular cytoplasm containing endogenous antigens is engulfed and placed in a autophagosome.
2. After a lysosome fuses with the autophagosome, these endogenous proteins are degraded by lysosomal proteases into peptides.
3. The peptides are directly transfered from the autophagolysosome to the vesicles containing the MHC-II molecules.
4. The MHC-II molecules with bound peptides are then transported to the surface of the dendritic cell where they can be presented to naive T4-lymphocytes.

Illustration of Cross-Presentation of Endogenous Antigens to MHC-II Molecules by a Dendritic Cell Through Autophagy .jpg by Gary E. Kaiser, Ph.D.
Professor of Microbiology, The Community College of Baltimore County, Catonsville Campus
This work is licensed under a Creative Commons Attribution 4.0 International License.
Based on a work at https://cwoer.ccbcmd.edu/science/microbiology/index_gos.html.

Last updated: August, 2019
Please send comments and inquiries to Dr. Gary Kaiser

Fig. 8: Cross-Presentation of Endogenous Antigens to MHC-II Molecules by a Dendritic Cell Through Autophagy

Fig. 8: Cross-Presentation of Endogenous Antigens to MHC-II Molecules
by a Dendritic Cell Through Autophagy